Peripherally Administered Nanoparticles Target Monocytic Myeloid Cells, Secondary Lymphoid Organs and Tumors in Mice
Identifieur interne : 003304 ( Main/Exploration ); précédent : 003303; suivant : 003305Peripherally Administered Nanoparticles Target Monocytic Myeloid Cells, Secondary Lymphoid Organs and Tumors in Mice
Auteurs : Iraklis C. Kourtis [Suisse] ; Sachiko Hirosue [Suisse] ; Alexandre De Titta [Suisse] ; Stephan Kontos [Suisse] ; Toon Stegmann [Pays-Bas] ; Jeffrey A. Hubbell [Suisse] ; Melody A. Swartz [Suisse]Source :
- PLoS ONE [ 1932-6203 ] ; 2013.
Abstract
Nanoparticles have been extensively developed for therapeutic and diagnostic applications. While the focus of nanoparticle trafficking
Url:
DOI: 10.1371/journal.pone.0061646
PubMed: 23626707
PubMed Central: 3633981
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 004473
- to stream Pmc, to step Curation: 004472
- to stream Pmc, to step Checkpoint: 002076
- to stream Ncbi, to step Merge: 005866
- to stream Ncbi, to step Curation: 005866
- to stream Ncbi, to step Checkpoint: 005866
- to stream Main, to step Merge: 003310
- to stream Main, to step Curation: 003304
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Peripherally Administered Nanoparticles Target Monocytic Myeloid Cells, Secondary Lymphoid Organs and Tumors in Mice</title><author><name sortKey="Kourtis, Iraklis C" sort="Kourtis, Iraklis C" uniqKey="Kourtis I" first="Iraklis C." last="Kourtis">Iraklis C. Kourtis</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Hirosue, Sachiko" sort="Hirosue, Sachiko" uniqKey="Hirosue S" first="Sachiko" last="Hirosue">Sachiko Hirosue</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="De Titta, Alexandre" sort="De Titta, Alexandre" uniqKey="De Titta A" first="Alexandre" last="De Titta">Alexandre De Titta</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Kontos, Stephan" sort="Kontos, Stephan" uniqKey="Kontos S" first="Stephan" last="Kontos">Stephan Kontos</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Stegmann, Toon" sort="Stegmann, Toon" uniqKey="Stegmann T" first="Toon" last="Stegmann">Toon Stegmann</name><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Mymetics BV, Leiden, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Mymetics BV, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Hubbell, Jeffrey A" sort="Hubbell, Jeffrey A" uniqKey="Hubbell J" first="Jeffrey A." last="Hubbell">Jeffrey A. Hubbell</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>Institute of Chemical Sciences and Engineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Chemical Sciences and Engineering, École Polytechnique Fédérale de Lausanne, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Swartz, Melody A" sort="Swartz, Melody A" uniqKey="Swartz M" first="Melody A." last="Swartz">Melody A. Swartz</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Swiss Institute for Experimental Cancer Research (ISREC), École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute for Experimental Cancer Research (ISREC), École Polytechnique Fédérale de Lausanne, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23626707</idno><idno type="pmc">3633981</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633981</idno><idno type="RBID">PMC:3633981</idno><idno type="doi">10.1371/journal.pone.0061646</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">004473</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004473</idno><idno type="wicri:Area/Pmc/Curation">004472</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004472</idno><idno type="wicri:Area/Pmc/Checkpoint">002076</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002076</idno><idno type="wicri:Area/Ncbi/Merge">005866</idno><idno type="wicri:Area/Ncbi/Curation">005866</idno><idno type="wicri:Area/Ncbi/Checkpoint">005866</idno><idno type="wicri:Area/Main/Merge">003310</idno><idno type="wicri:Area/Main/Curation">003304</idno><idno type="wicri:Area/Main/Exploration">003304</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Peripherally Administered Nanoparticles Target Monocytic Myeloid Cells, Secondary Lymphoid Organs and Tumors in Mice</title><author><name sortKey="Kourtis, Iraklis C" sort="Kourtis, Iraklis C" uniqKey="Kourtis I" first="Iraklis C." last="Kourtis">Iraklis C. Kourtis</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Hirosue, Sachiko" sort="Hirosue, Sachiko" uniqKey="Hirosue S" first="Sachiko" last="Hirosue">Sachiko Hirosue</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="De Titta, Alexandre" sort="De Titta, Alexandre" uniqKey="De Titta A" first="Alexandre" last="De Titta">Alexandre De Titta</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Kontos, Stephan" sort="Kontos, Stephan" uniqKey="Kontos S" first="Stephan" last="Kontos">Stephan Kontos</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Stegmann, Toon" sort="Stegmann, Toon" uniqKey="Stegmann T" first="Toon" last="Stegmann">Toon Stegmann</name><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Mymetics BV, Leiden, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Mymetics BV, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Hubbell, Jeffrey A" sort="Hubbell, Jeffrey A" uniqKey="Hubbell J" first="Jeffrey A." last="Hubbell">Jeffrey A. Hubbell</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>Institute of Chemical Sciences and Engineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Chemical Sciences and Engineering, École Polytechnique Fédérale de Lausanne, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Swartz, Melody A" sort="Swartz, Melody A" uniqKey="Swartz M" first="Melody A." last="Swartz">Melody A. Swartz</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Swiss Institute for Experimental Cancer Research (ISREC), École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute for Experimental Cancer Research (ISREC), École Polytechnique Fédérale de Lausanne, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Nanoparticles have been extensively developed for therapeutic and diagnostic applications. While the focus of nanoparticle trafficking <italic>in vivo</italic> has traditionally been on drug delivery and organ-level biodistribution and clearance, recent work in cancer biology and infectious disease suggests that targeting different cells within a given organ can substantially affect the quality of the immunological response. Here, we examine the cell-level biodistribution kinetics after administering ultrasmall Pluronic-stabilized poly(propylene sulfide) nanoparticles in the mouse. These nanoparticles depend on lymphatic drainage to reach the lymph nodes and blood, and then enter the spleen rather than the liver, where they interact with monocytes, macrophages and myeloid dendritic cells. They were more readily taken up into lymphatics after intradermal (i.d.) compared to intramuscular administration, leading to ∼50% increased bioavailability in blood. When administered i.d., their distribution favored antigen-presenting cells, with especially strong targeting to myeloid cells. In tumor-bearing mice, the monocytic and the polymorphonuclear myeloid-derived suppressor cell compartments were efficiently and preferentially targeted, rendering this nanoparticulate formulation potentially useful for reversing the highly suppressive activity of these cells in the tumor stroma.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Davis, Me" uniqKey="Davis M">ME Davis</name></author><author><name sortKey="Chen, Zg" uniqKey="Chen Z">ZG Chen</name></author><author><name sortKey="Shin, Dm" uniqKey="Shin D">DM Shin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taylor, A" uniqKey="Taylor A">A Taylor</name></author><author><name sortKey="Wilson, Km" uniqKey="Wilson K">KM Wilson</name></author><author><name sortKey="Murray, P" uniqKey="Murray P">P Murray</name></author><author><name sortKey="Fernig, Dg" uniqKey="Fernig D">DG Fernig</name></author><author><name sortKey="Levy, R" uniqKey="Levy R">R Levy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bachmann, Mf" uniqKey="Bachmann M">MF Bachmann</name></author><author><name sortKey="Jennings, Gt" uniqKey="Jennings G">GT Jennings</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Petros, Ra" uniqKey="Petros R">RA Petros</name></author><author><name sortKey="Desimone, Jm" uniqKey="Desimone J">JM DeSimone</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sugahara, Kn" uniqKey="Sugahara K">KN Sugahara</name></author><author><name sortKey="Teesalu, T" uniqKey="Teesalu T">T Teesalu</name></author><author><name sortKey="Karmali, Pp" uniqKey="Karmali P">PP Karmali</name></author><author><name sortKey="Kotamraju, Vr" uniqKey="Kotamraju V">VR Kotamraju</name></author><author><name sortKey="Agemy, L" uniqKey="Agemy L">L Agemy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Von Maltzahn, G" uniqKey="Von Maltzahn G">G von Maltzahn</name></author><author><name sortKey="Ren, Y" uniqKey="Ren Y">Y Ren</name></author><author><name sortKey="Park, Jh" uniqKey="Park J">JH Park</name></author><author><name sortKey="Min, Dh" uniqKey="Min D">DH Min</name></author><author><name sortKey="Kotamraju, Vr" uniqKey="Kotamraju V">VR Kotamraju</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Serda, Re" uniqKey="Serda R">RE Serda</name></author><author><name sortKey="Godin, B" uniqKey="Godin B">B Godin</name></author><author><name sortKey="Blanco, E" uniqKey="Blanco E">E Blanco</name></author><author><name sortKey="Chiappini, C" uniqKey="Chiappini C">C Chiappini</name></author><author><name sortKey="Ferrari, M" uniqKey="Ferrari M">M Ferrari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hirosue, S" uniqKey="Hirosue S">S Hirosue</name></author><author><name sortKey="Kourtis, Ic" uniqKey="Kourtis I">IC Kourtis</name></author><author><name sortKey="Van Der Vlies, Aj" uniqKey="Van Der Vlies A">AJ van der Vlies</name></author><author><name sortKey="Hubbell, Ja" uniqKey="Hubbell J">JA Hubbell</name></author><author><name sortKey="Swartz, Ma" uniqKey="Swartz M">MA Swartz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nembrini, C" uniqKey="Nembrini C">C Nembrini</name></author><author><name sortKey="Stano, A" uniqKey="Stano A">A Stano</name></author><author><name sortKey="Dane, Ky" uniqKey="Dane K">KY Dane</name></author><author><name sortKey="Ballester, M" uniqKey="Ballester M">M Ballester</name></author><author><name sortKey="Van Der Vlies, Aj" uniqKey="Van Der Vlies A">AJ van der Vlies</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reddy, St" uniqKey="Reddy S">ST Reddy</name></author><author><name sortKey="Van Der Vlies, Aj" uniqKey="Van Der Vlies A">AJ van der Vlies</name></author><author><name sortKey="Simeoni, E" uniqKey="Simeoni E">E Simeoni</name></author><author><name sortKey="Angeli, V" uniqKey="Angeli V">V Angeli</name></author><author><name sortKey="Randolph, Gj" uniqKey="Randolph G">GJ Randolph</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stephan, Mt" uniqKey="Stephan M">MT Stephan</name></author><author><name sortKey="Moon, Jj" uniqKey="Moon J">JJ Moon</name></author><author><name sortKey="Um, Sh" uniqKey="Um S">SH Um</name></author><author><name sortKey="Bershteyn, A" uniqKey="Bershteyn A">A Bershteyn</name></author><author><name sortKey="Irvine, Dj" uniqKey="Irvine D">DJ Irvine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schrand, Am" uniqKey="Schrand A">AM Schrand</name></author><author><name sortKey="Dai, L" uniqKey="Dai L">L Dai</name></author><author><name sortKey="Schlager, Jj" uniqKey="Schlager J">JJ Schlager</name></author><author><name sortKey="Hussain, Sm" uniqKey="Hussain S">SM Hussain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Manolova, V" uniqKey="Manolova V">V Manolova</name></author><author><name sortKey="Flace, A" uniqKey="Flace A">A Flace</name></author><author><name sortKey="Bauer, M" uniqKey="Bauer M">M Bauer</name></author><author><name sortKey="Schwarz, K" uniqKey="Schwarz K">K Schwarz</name></author><author><name sortKey="Saudan, P" uniqKey="Saudan P">P Saudan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reddy, St" uniqKey="Reddy S">ST Reddy</name></author><author><name sortKey="Swartz, Ma" uniqKey="Swartz M">MA Swartz</name></author><author><name sortKey="Hubbell, Ja" uniqKey="Hubbell J">JA Hubbell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jewell, Cm" uniqKey="Jewell C">CM Jewell</name></author><author><name sortKey="Lopez, Sc" uniqKey="Lopez S">SC Lopez</name></author><author><name sortKey="Irvine, Dj" uniqKey="Irvine D">DJ Irvine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reddy, St" uniqKey="Reddy S">ST Reddy</name></author><author><name sortKey="Rehor, A" uniqKey="Rehor A">A Rehor</name></author><author><name sortKey="Schmoekel, Hg" uniqKey="Schmoekel H">HG Schmoekel</name></author><author><name sortKey="Hubbell, Ja" uniqKey="Hubbell J">JA Hubbell</name></author><author><name sortKey="Swartz, Ma" uniqKey="Swartz M">MA Swartz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kasturi, Sp" uniqKey="Kasturi S">SP Kasturi</name></author><author><name sortKey="Skountzou, I" uniqKey="Skountzou I">I Skountzou</name></author><author><name sortKey="Albrecht, Ra" uniqKey="Albrecht R">RA Albrecht</name></author><author><name sortKey="Koutsonanos, D" uniqKey="Koutsonanos D">D Koutsonanos</name></author><author><name sortKey="Hua, T" uniqKey="Hua T">T Hua</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Iannacone, M" uniqKey="Iannacone M">M Iannacone</name></author><author><name sortKey="Moseman, Ea" uniqKey="Moseman E">EA Moseman</name></author><author><name sortKey="Tonti, E" uniqKey="Tonti E">E Tonti</name></author><author><name sortKey="Bosurgi, L" uniqKey="Bosurgi L">L Bosurgi</name></author><author><name sortKey="Junt, T" uniqKey="Junt T">T Junt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gonzalez, Sf" uniqKey="Gonzalez S">SF Gonzalez</name></author><author><name sortKey="Lukacs Kornek, V" uniqKey="Lukacs Kornek V">V Lukacs-Kornek</name></author><author><name sortKey="Kuligowski, Mp" uniqKey="Kuligowski M">MP Kuligowski</name></author><author><name sortKey="Pitcher, La" uniqKey="Pitcher L">LA Pitcher</name></author><author><name sortKey="Degn, Se" uniqKey="Degn S">SE Degn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roozendaal, R" uniqKey="Roozendaal R">R Roozendaal</name></author><author><name sortKey="Mempel, Tr" uniqKey="Mempel T">TR Mempel</name></author><author><name sortKey="Pitcher, La" uniqKey="Pitcher L">LA Pitcher</name></author><author><name sortKey="Gonzalez, Sf" uniqKey="Gonzalez S">SF Gonzalez</name></author><author><name sortKey="Verschoor, A" uniqKey="Verschoor A">A Verschoor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ballester, M" uniqKey="Ballester M">M Ballester</name></author><author><name sortKey="Nembrini, C" uniqKey="Nembrini C">C Nembrini</name></author><author><name sortKey="Dhar, N" uniqKey="Dhar N">N Dhar</name></author><author><name sortKey="De Titta, A" uniqKey="De Titta A">A de Titta</name></author><author><name sortKey="De Piano, C" uniqKey="De Piano C">C de Piano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="M Kinen, T" uniqKey="M Kinen T">T Mäkinen</name></author><author><name sortKey="Jussila, L" uniqKey="Jussila L">L Jussila</name></author><author><name sortKey="Veikkola, T" uniqKey="Veikkola T">T Veikkola</name></author><author><name sortKey="Karpanen, T" uniqKey="Karpanen T">T Karpanen</name></author><author><name sortKey="Kettunen, Mi" uniqKey="Kettunen M">MI Kettunen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Der Vlies, Aj" uniqKey="Van Der Vlies A">AJ van der Vlies</name></author><author><name sortKey="O Neil, Cp" uniqKey="O Neil C">CP O'Neil</name></author><author><name sortKey="Hasegawa, U" uniqKey="Hasegawa U">U Hasegawa</name></author><author><name sortKey="Hammond, N" uniqKey="Hammond N">N Hammond</name></author><author><name sortKey="Hubbell, Ja" uniqKey="Hubbell J">JA Hubbell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cribari Neto, F" uniqKey="Cribari Neto F">F Cribari-Neto</name></author><author><name sortKey="Zeileis, A" uniqKey="Zeileis A">A Zeileis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maldiney, T" uniqKey="Maldiney T">T Maldiney</name></author><author><name sortKey="Richard, C" uniqKey="Richard C">C Richard</name></author><author><name sortKey="Seguin, J" uniqKey="Seguin J">J Seguin</name></author><author><name sortKey="Wattier, N" uniqKey="Wattier N">N Wattier</name></author><author><name sortKey="Bessodes, M" uniqKey="Bessodes M">M Bessodes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Phan, Tg" uniqKey="Phan T">TG Phan</name></author><author><name sortKey="Grigorova, I" uniqKey="Grigorova I">I Grigorova</name></author><author><name sortKey="Okada, T" uniqKey="Okada T">T Okada</name></author><author><name sortKey="Cyster, Jg" uniqKey="Cyster J">JG Cyster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Junt, T" uniqKey="Junt T">T Junt</name></author><author><name sortKey="Moseman, Ea" uniqKey="Moseman E">EA Moseman</name></author><author><name sortKey="Iannacone, M" uniqKey="Iannacone M">M Iannacone</name></author><author><name sortKey="Massberg, S" uniqKey="Massberg S">S Massberg</name></author><author><name sortKey="Lang, Pa" uniqKey="Lang P">PA Lang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kang, Ys" uniqKey="Kang Y">YS Kang</name></author><author><name sortKey="Kim, Jy" uniqKey="Kim J">JY Kim</name></author><author><name sortKey="Bruening, Sa" uniqKey="Bruening S">SA Bruening</name></author><author><name sortKey="Pack, M" uniqKey="Pack M">M Pack</name></author><author><name sortKey="Charalambous, A" uniqKey="Charalambous A">A Charalambous</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hickman, Hd" uniqKey="Hickman H">HD Hickman</name></author><author><name sortKey="Li, L" uniqKey="Li L">L Li</name></author><author><name sortKey="Reynoso, Gv" uniqKey="Reynoso G">GV Reynoso</name></author><author><name sortKey="Rubin, Ej" uniqKey="Rubin E">EJ Rubin</name></author><author><name sortKey="Skon, Cn" uniqKey="Skon C">CN Skon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Jong, Ec" uniqKey="De Jong E">EC de Jong</name></author><author><name sortKey="Smits, Hh" uniqKey="Smits H">HH Smits</name></author><author><name sortKey="Kapsenberg, Ml" uniqKey="Kapsenberg M">ML Kapsenberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Steinman, Rm" uniqKey="Steinman R">RM Steinman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Steinman, Rm" uniqKey="Steinman R">RM Steinman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mclellan, Ad" uniqKey="Mclellan A">AD McLellan</name></author><author><name sortKey="Kampgen, E" uniqKey="Kampgen E">E Kampgen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ohl, L" uniqKey="Ohl L">L Ohl</name></author><author><name sortKey="Mohaupt, M" uniqKey="Mohaupt M">M Mohaupt</name></author><author><name sortKey="Czeloth, N" uniqKey="Czeloth N">N Czeloth</name></author><author><name sortKey="Hintzen, G" uniqKey="Hintzen G">G Hintzen</name></author><author><name sortKey="Kiafard, Z" uniqKey="Kiafard Z">Z Kiafard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tal, O" uniqKey="Tal O">O Tal</name></author><author><name sortKey="Lim, Hy" uniqKey="Lim H">HY Lim</name></author><author><name sortKey="Gurevich, I" uniqKey="Gurevich I">I Gurevich</name></author><author><name sortKey="Milo, I" uniqKey="Milo I">I Milo</name></author><author><name sortKey="Shipony, Z" uniqKey="Shipony Z">Z Shipony</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Den Haan, Jm" uniqKey="Den Haan J">JM den Haan</name></author><author><name sortKey="Lehar, Sm" uniqKey="Lehar S">SM Lehar</name></author><author><name sortKey="Bevan, Mj" uniqKey="Bevan M">MJ Bevan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gasparini, R" uniqKey="Gasparini R">R Gasparini</name></author><author><name sortKey="Lai, P" uniqKey="Lai P">P Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kaneda, Y" uniqKey="Kaneda Y">Y Kaneda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hamad, I" uniqKey="Hamad I">I Hamad</name></author><author><name sortKey="Al Hanbali, O" uniqKey="Al Hanbali O">O Al-Hanbali</name></author><author><name sortKey="Hunter, Ac" uniqKey="Hunter A">AC Hunter</name></author><author><name sortKey="Rutt, Kj" uniqKey="Rutt K">KJ Rutt</name></author><author><name sortKey="Andresen, Tl" uniqKey="Andresen T">TL Andresen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cubas, R" uniqKey="Cubas R">R Cubas</name></author><author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name></author><author><name sortKey="Kwon, S" uniqKey="Kwon S">S Kwon</name></author><author><name sortKey="Sevick Muraca, Em" uniqKey="Sevick Muraca E">EM Sevick-Muraca</name></author><author><name sortKey="Li, M" uniqKey="Li M">M Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kang, Sm" uniqKey="Kang S">SM Kang</name></author><author><name sortKey="Song, Jm" uniqKey="Song J">JM Song</name></author><author><name sortKey="Kim, Yc" uniqKey="Kim Y">YC Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nicolas, Jf" uniqKey="Nicolas J">JF Nicolas</name></author><author><name sortKey="Guy, B" uniqKey="Guy B">B Guy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Allan, Rs" uniqKey="Allan R">RS Allan</name></author><author><name sortKey="Smith, Cm" uniqKey="Smith C">CM Smith</name></author><author><name sortKey="Belz, Gt" uniqKey="Belz G">GT Belz</name></author><author><name sortKey="Van Lint, Al" uniqKey="Van Lint A">AL van Lint</name></author><author><name sortKey="Wakim, Lm" uniqKey="Wakim L">LM Wakim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reis E Sousa, C" uniqKey="Reis E Sousa C">C Reis e Sousa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thomas, Sn" uniqKey="Thomas S">SN Thomas</name></author><author><name sortKey="Rutkowski, Jm" uniqKey="Rutkowski J">JM Rutkowski</name></author><author><name sortKey="Pasquier, M" uniqKey="Pasquier M">M Pasquier</name></author><author><name sortKey="Kuan, El" uniqKey="Kuan E">EL Kuan</name></author><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Katakai, T" uniqKey="Katakai T">T Katakai</name></author><author><name sortKey="Hara, T" uniqKey="Hara T">T Hara</name></author><author><name sortKey="Sugai, M" uniqKey="Sugai M">M Sugai</name></author><author><name sortKey="Gonda, H" uniqKey="Gonda H">H Gonda</name></author><author><name sortKey="Shimizu, A" uniqKey="Shimizu A">A Shimizu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mebius, Re" uniqKey="Mebius R">RE Mebius</name></author><author><name sortKey="Kraal, G" uniqKey="Kraal G">G Kraal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Swirski, Fk" uniqKey="Swirski F">FK Swirski</name></author><author><name sortKey="Nahrendorf, M" uniqKey="Nahrendorf M">M Nahrendorf</name></author><author><name sortKey="Etzrodt, M" uniqKey="Etzrodt M">M Etzrodt</name></author><author><name sortKey="Wildgruber, M" uniqKey="Wildgruber M">M Wildgruber</name></author><author><name sortKey="Cortez Retamozo, V" uniqKey="Cortez Retamozo V">V Cortez-Retamozo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stephan, Mt" uniqKey="Stephan M">MT Stephan</name></author><author><name sortKey="Stephan, S" uniqKey="Stephan S">S Stephan</name></author><author><name sortKey="Bak, Sp" uniqKey="Bak S">SP Bak</name></author><author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name></author><author><name sortKey="Irvine, Dj" uniqKey="Irvine D">DJ Irvine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gabrilovich, Di" uniqKey="Gabrilovich D">DI Gabrilovich</name></author><author><name sortKey="Nagaraj, S" uniqKey="Nagaraj S">S Nagaraj</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Movahedi, K" uniqKey="Movahedi K">K Movahedi</name></author><author><name sortKey="Guilliams, M" uniqKey="Guilliams M">M Guilliams</name></author><author><name sortKey="Van Den Bossche, J" uniqKey="Van Den Bossche J">J Van den Bossche</name></author><author><name sortKey="Van Den Bergh, R" uniqKey="Van Den Bergh R">R Van den Bergh</name></author><author><name sortKey="Gysemans, C" uniqKey="Gysemans C">C Gysemans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shields, Jd" uniqKey="Shields J">JD Shields</name></author><author><name sortKey="Kourtis, Ic" uniqKey="Kourtis I">IC Kourtis</name></author><author><name sortKey="Tomei, Aa" uniqKey="Tomei A">AA Tomei</name></author><author><name sortKey="Roberts, Jm" uniqKey="Roberts J">JM Roberts</name></author><author><name sortKey="Swartz, Ma" uniqKey="Swartz M">MA Swartz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nagaraj, S" uniqKey="Nagaraj S">S Nagaraj</name></author><author><name sortKey="Gabrilovich, Di" uniqKey="Gabrilovich D">DI Gabrilovich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ostrand Rosenberg, S" uniqKey="Ostrand Rosenberg S">S Ostrand-Rosenberg</name></author><author><name sortKey="Sinha, P" uniqKey="Sinha P">P Sinha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buono, C" uniqKey="Buono C">C Buono</name></author><author><name sortKey="Anzinger, Jj" uniqKey="Anzinger J">JJ Anzinger</name></author><author><name sortKey="Amar, M" uniqKey="Amar M">M Amar</name></author><author><name sortKey="Kruth, Hs" uniqKey="Kruth H">HS Kruth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leuschner, F" uniqKey="Leuschner F">F Leuschner</name></author><author><name sortKey="Dutta, P" uniqKey="Dutta P">P Dutta</name></author><author><name sortKey="Gorbatov, R" uniqKey="Gorbatov R">R Gorbatov</name></author><author><name sortKey="Novobrantseva, Ti" uniqKey="Novobrantseva T">TI Novobrantseva</name></author><author><name sortKey="Donahoe, Js" uniqKey="Donahoe J">JS Donahoe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shi, C" uniqKey="Shi C">C Shi</name></author><author><name sortKey="Pamer, Eg" uniqKey="Pamer E">EG Pamer</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Pays-Bas</li><li>Suisse</li></country><region><li>Canton de Vaud</li><li>Hollande-Méridionale</li></region><settlement><li>Lausanne</li><li>Leyde</li></settlement></list><tree><country name="Suisse"><region name="Canton de Vaud"><name sortKey="Kourtis, Iraklis C" sort="Kourtis, Iraklis C" uniqKey="Kourtis I" first="Iraklis C." last="Kourtis">Iraklis C. Kourtis</name></region><name sortKey="De Titta, Alexandre" sort="De Titta, Alexandre" uniqKey="De Titta A" first="Alexandre" last="De Titta">Alexandre De Titta</name><name sortKey="Hirosue, Sachiko" sort="Hirosue, Sachiko" uniqKey="Hirosue S" first="Sachiko" last="Hirosue">Sachiko Hirosue</name><name sortKey="Hubbell, Jeffrey A" sort="Hubbell, Jeffrey A" uniqKey="Hubbell J" first="Jeffrey A." last="Hubbell">Jeffrey A. Hubbell</name><name sortKey="Hubbell, Jeffrey A" sort="Hubbell, Jeffrey A" uniqKey="Hubbell J" first="Jeffrey A." last="Hubbell">Jeffrey A. Hubbell</name><name sortKey="Kontos, Stephan" sort="Kontos, Stephan" uniqKey="Kontos S" first="Stephan" last="Kontos">Stephan Kontos</name><name sortKey="Swartz, Melody A" sort="Swartz, Melody A" uniqKey="Swartz M" first="Melody A." last="Swartz">Melody A. Swartz</name><name sortKey="Swartz, Melody A" sort="Swartz, Melody A" uniqKey="Swartz M" first="Melody A." last="Swartz">Melody A. Swartz</name></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Stegmann, Toon" sort="Stegmann, Toon" uniqKey="Stegmann T" first="Toon" last="Stegmann">Toon Stegmann</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003304 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003304 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3633981
|texte= Peripherally Administered Nanoparticles Target Monocytic Myeloid Cells, Secondary Lymphoid Organs and Tumors in Mice
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:23626707" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |